Apramycin sulfate( Nebramycin II )

Catalog No. M15500 CAS No. 65710-07-8

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Product Name

Apramycin sulfate
Note

Research use only, not for human use.
Brief Description

Apramycin sulfate is an aminoglycoside antibiotic mproduced by a strain of Streptomyces tenebrarius, used in veterinary practice.
Description

Apramycin sulfate is an aminoglycoside antibiotic mproduced by a strain of Streptomyces tenebrarius, used in veterinary practice.
In Vitro

——
In Vivo

Animal Model:M. tuberculosis low-dose aerosol infection model of IFN-γ knockout mice Dosage:200 mg/kg/d Administration:Subcutaneous injection (s.c.) for 9 d Result:Showed a 2.4-log10 CFU reduction and better antituberculous activity compared to Amikacin (1.8-log10 reduction).
Synonyms

Nebramycin II
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

16S rRNA
Research Area

Infection
Indication

——

CAS Number

65710-07-8
Formula Weight

637.66
Molecular Formula

C21H43N5O15S
Purity

>98% (HPLC)
Solubility

Water: 100 mg/mL (156.82 mM)
SMILES

O[C@H]1[C@@H](O[C@@H]2[C@@H](NC)[C@@H](O)[C@]3([H])[C@@](C[C@@H](N)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](N)C[C@@H]4N)O3)([H])O2)O[C@H](CO)[C@@H](N)[C@@H]1O.O=S(O)(O)=O
Chemical Name

(2R,3R,4S,5S,6S)-2-[[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-5-amino-6-(hydroxymethyl)oxane-3,4-diol sulfuric acid

1. Woodcock J, et al. EMBO J. 1991 Oct; 10(10):3099-103.

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